Protein kinase FgSch9 serves as a mediator of the target of rapamycin and high osmolarity glycerol pathways and regulates multiple stress responses and secondary metabolism in Fusarium graminearum.
Identifieur interne : 000C36 ( Main/Exploration ); précédent : 000C35; suivant : 000C37Protein kinase FgSch9 serves as a mediator of the target of rapamycin and high osmolarity glycerol pathways and regulates multiple stress responses and secondary metabolism in Fusarium graminearum.
Auteurs : Qin Gu [République populaire de Chine] ; Chengqi Zhang [République populaire de Chine] ; Fangwei Yu [République populaire de Chine] ; Yanni Yin [République populaire de Chine] ; Won-Bo Shim [États-Unis] ; Zhonghua Ma [République populaire de Chine]Source :
- Environmental microbiology [ 1462-2920 ] ; 2015.
Descripteurs français
- KwdFr :
- Concentration osmolaire (MeSH), Facteurs de transcription (métabolisme), Fusarium (enzymologie), Fusarium (génétique), Fusarium (pathogénicité), Glycérol (métabolisme), Hyphae (métabolisme), Mycotoxines (biosynthèse), Métabolisme secondaire (MeSH), Paroi cellulaire (métabolisme), Pression osmotique (MeSH), Protein kinases (métabolisme), Protéines fongiques (métabolisme), Spores fongiques (métabolisme), Stress oxydatif (MeSH), Sérine-thréonine kinases TOR (métabolisme), Virulence (MeSH).
- MESH :
- biosynthèse : Mycotoxines.
- enzymologie : Fusarium.
- génétique : Fusarium.
- métabolisme : Facteurs de transcription, Glycérol, Hyphae, Paroi cellulaire, Protein kinases, Protéines fongiques, Spores fongiques, Sérine-thréonine kinases TOR.
- pathogénicité : Fusarium.
- Concentration osmolaire, Métabolisme secondaire, Pression osmotique, Stress oxydatif, Virulence.
English descriptors
- KwdEn :
- Cell Wall (metabolism), Fungal Proteins (metabolism), Fusarium (enzymology), Fusarium (genetics), Fusarium (pathogenicity), Glycerol (metabolism), Hyphae (metabolism), Mycotoxins (biosynthesis), Osmolar Concentration (MeSH), Osmotic Pressure (MeSH), Oxidative Stress (MeSH), Protein Kinases (metabolism), Secondary Metabolism (MeSH), Spores, Fungal (metabolism), TOR Serine-Threonine Kinases (metabolism), Transcription Factors (metabolism), Virulence (MeSH).
- MESH :
- chemical , biosynthesis : Mycotoxins.
- chemical , metabolism : Fungal Proteins, Glycerol, Protein Kinases, TOR Serine-Threonine Kinases, Transcription Factors.
- enzymology : Fusarium.
- genetics : Fusarium.
- metabolism : Cell Wall, Hyphae, Spores, Fungal.
- pathogenicity : Fusarium.
- Osmolar Concentration, Osmotic Pressure, Oxidative Stress, Secondary Metabolism, Virulence.
Abstract
Saccharomyces cerevisiae protein kinase Sch9 is one of the downstream effectors of the target of rapamycin (TOR) complex 1 and plays multiple roles in stress resistance, longevity and nutrient sensing. However, the functions of Sch9 orthologs in filamentous fungi, particularly in pathogenic species, have not been characterized to date. Here, we investigated biological and genetic functions of FgSch9 in Fusarium graminearum. The FgSCH9 deletion mutant (ΔFgSch9) was defective in aerial hyphal growth, hyphal branching and conidial germination. The mutant exhibited increased sensitivity to osmotic and oxidative stresses, cell wall-damaging agents, and to rapamycin, while showing increased thermal tolerance. We identified FgMaf1 as one of the FgSch9-interacting proteins that plays an important role in regulating mycotoxin biosynthesis and virulence of F. graminearum. Co-immunoprecipitation and affinity capture-mass spectrometry assays showed that FgSch9 also interacts with FgTor and FgHog1. More importantly, both ΔFgSch9 and FgHog1 null mutant (ΔFgHog1) exhibited increased sensitivity to osmotic and oxidative stresses. This defect was more severe in the FgSch9/FgHog1 double mutant. Taken together, we propose that FgSch9 serves as a mediator of the TOR and high osmolarity glycerol pathways, and regulates vegetative differentiation, multiple stress responses and secondary metabolism in F. graminearum.
DOI: 10.1111/1462-2920.12522
PubMed: 24903410
Affiliations:
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Le document en format XML
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xml:lang="en"><term>Cell Wall (metabolism)</term><term>Fungal Proteins (metabolism)</term><term>Fusarium (enzymology)</term><term>Fusarium (genetics)</term><term>Fusarium (pathogenicity)</term><term>Glycerol (metabolism)</term><term>Hyphae (metabolism)</term><term>Mycotoxins (biosynthesis)</term><term>Osmolar Concentration (MeSH)</term><term>Osmotic Pressure (MeSH)</term><term>Oxidative Stress (MeSH)</term><term>Protein Kinases (metabolism)</term><term>Secondary Metabolism (MeSH)</term><term>Spores, Fungal (metabolism)</term><term>TOR Serine-Threonine Kinases (metabolism)</term><term>Transcription Factors (metabolism)</term><term>Virulence (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Concentration osmolaire (MeSH)</term><term>Facteurs de transcription (métabolisme)</term><term>Fusarium (enzymologie)</term><term>Fusarium (génétique)</term><term>Fusarium (pathogénicité)</term><term>Glycérol (métabolisme)</term><term>Hyphae (métabolisme)</term><term>Mycotoxines (biosynthèse)</term><term>Métabolisme secondaire (MeSH)</term><term>Paroi cellulaire (métabolisme)</term><term>Pression osmotique (MeSH)</term><term>Protein kinases (métabolisme)</term><term>Protéines fongiques (métabolisme)</term><term>Spores fongiques (métabolisme)</term><term>Stress oxydatif (MeSH)</term><term>Sérine-thréonine kinases TOR (métabolisme)</term><term>Virulence (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Mycotoxins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fungal Proteins</term><term>Glycerol</term><term>Protein Kinases</term><term>TOR Serine-Threonine Kinases</term><term>Transcription Factors</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Mycotoxines</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Fusarium</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Fusarium</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Fusarium</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Fusarium</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Wall</term><term>Hyphae</term><term>Spores, Fungal</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de transcription</term><term>Glycérol</term><term>Hyphae</term><term>Paroi cellulaire</term><term>Protein kinases</term><term>Protéines fongiques</term><term>Spores fongiques</term><term>Sérine-thréonine kinases TOR</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Fusarium</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Fusarium</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Osmolar Concentration</term><term>Osmotic Pressure</term><term>Oxidative Stress</term><term>Secondary Metabolism</term><term>Virulence</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Concentration osmolaire</term><term>Métabolisme secondaire</term><term>Pression osmotique</term><term>Stress oxydatif</term><term>Virulence</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Saccharomyces cerevisiae protein kinase Sch9 is one of the downstream effectors of the target of rapamycin (TOR) complex 1 and plays multiple roles in stress resistance, longevity and nutrient sensing. However, the functions of Sch9 orthologs in filamentous fungi, particularly in pathogenic species, have not been characterized to date. Here, we investigated biological and genetic functions of FgSch9 in Fusarium graminearum. The FgSCH9 deletion mutant (ΔFgSch9) was defective in aerial hyphal growth, hyphal branching and conidial germination. The mutant exhibited increased sensitivity to osmotic and oxidative stresses, cell wall-damaging agents, and to rapamycin, while showing increased thermal tolerance. We identified FgMaf1 as one of the FgSch9-interacting proteins that plays an important role in regulating mycotoxin biosynthesis and virulence of F. graminearum. Co-immunoprecipitation and affinity capture-mass spectrometry assays showed that FgSch9 also interacts with FgTor and FgHog1. More importantly, both ΔFgSch9 and FgHog1 null mutant (ΔFgHog1) exhibited increased sensitivity to osmotic and oxidative stresses. This defect was more severe in the FgSch9/FgHog1 double mutant. Taken together, we propose that FgSch9 serves as a mediator of the TOR and high osmolarity glycerol pathways, and regulates vegetative differentiation, multiple stress responses and secondary metabolism in F. graminearum. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">24903410</PMID><DateCompleted><Year>2016</Year><Month>04</Month><Day>18</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1462-2920</ISSN><JournalIssue CitedMedium="Internet"><Volume>17</Volume><Issue>8</Issue><PubDate><Year>2015</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Environmental microbiology</Title><ISOAbbreviation>Environ Microbiol</ISOAbbreviation></Journal><ArticleTitle>Protein kinase FgSch9 serves as a mediator of the target of rapamycin and high osmolarity glycerol pathways and regulates multiple stress responses and secondary metabolism in Fusarium graminearum.</ArticleTitle><Pagination><MedlinePgn>2661-76</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/1462-2920.12522</ELocationID><Abstract><AbstractText>Saccharomyces cerevisiae protein kinase Sch9 is one of the downstream effectors of the target of rapamycin (TOR) complex 1 and plays multiple roles in stress resistance, longevity and nutrient sensing. However, the functions of Sch9 orthologs in filamentous fungi, particularly in pathogenic species, have not been characterized to date. Here, we investigated biological and genetic functions of FgSch9 in Fusarium graminearum. The FgSCH9 deletion mutant (ΔFgSch9) was defective in aerial hyphal growth, hyphal branching and conidial germination. The mutant exhibited increased sensitivity to osmotic and oxidative stresses, cell wall-damaging agents, and to rapamycin, while showing increased thermal tolerance. We identified FgMaf1 as one of the FgSch9-interacting proteins that plays an important role in regulating mycotoxin biosynthesis and virulence of F. graminearum. Co-immunoprecipitation and affinity capture-mass spectrometry assays showed that FgSch9 also interacts with FgTor and FgHog1. More importantly, both ΔFgSch9 and FgHog1 null mutant (ΔFgHog1) exhibited increased sensitivity to osmotic and oxidative stresses. This defect was more severe in the FgSch9/FgHog1 double mutant. Taken together, we propose that FgSch9 serves as a mediator of the TOR and high osmolarity glycerol pathways, and regulates vegetative differentiation, multiple stress responses and secondary metabolism in F. graminearum. </AbstractText><CopyrightInformation>© 2014 Society for Applied Microbiology and John Wiley & Sons Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gu</LastName><ForeName>Qin</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Institute of Biotechnology, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Chengqi</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Biotechnology, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Fangwei</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Institute of Biotechnology, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yin</LastName><ForeName>Yanni</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Institute of Biotechnology, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shim</LastName><ForeName>Won-Bo</ForeName><Initials>WB</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology and Microbiology, Texas A&M University, College Station, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>Zhonghua</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Institute of Biotechnology, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>06</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Environ Microbiol</MedlineTA><NlmUniqueID>100883692</NlmUniqueID><ISSNLinking>1462-2912</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005656">Fungal Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009183">Mycotoxins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014157">Transcription Factors</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.-</RegistryNumber><NameOfSubstance UI="D011494">Protein Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.-</RegistryNumber><NameOfSubstance UI="C071569">SCH9 protein kinase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber><NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>PDC6A3C0OX</RegistryNumber><NameOfSubstance UI="D005990">Glycerol</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D002473" MajorTopicYN="N">Cell Wall</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005656" MajorTopicYN="N">Fungal Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005670" MajorTopicYN="N">Fusarium</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005990" MajorTopicYN="N">Glycerol</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D025301" MajorTopicYN="N">Hyphae</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009183" MajorTopicYN="N">Mycotoxins</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009994" MajorTopicYN="N">Osmolar Concentration</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009997" MajorTopicYN="Y">Osmotic Pressure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="Y">Oxidative Stress</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011494" MajorTopicYN="N">Protein Kinases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D064210" MajorTopicYN="N">Secondary Metabolism</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013172" MajorTopicYN="N">Spores, Fungal</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014157" MajorTopicYN="N">Transcription Factors</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014774" MajorTopicYN="N">Virulence</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>02</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>05</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>05</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>6</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>6</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>4</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24903410</ArticleId><ArticleId IdType="doi">10.1111/1462-2920.12522</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Texas</li><li>Zhejiang</li></region><settlement><li>Hangzhou</li></settlement><orgName><li>Université de Zhejiang</li></orgName></list><tree><country name="République populaire de Chine"><region name="Zhejiang"><name sortKey="Gu, Qin" sort="Gu, Qin" uniqKey="Gu Q" first="Qin" last="Gu">Qin Gu</name></region><name sortKey="Ma, Zhonghua" sort="Ma, Zhonghua" uniqKey="Ma Z" first="Zhonghua" last="Ma">Zhonghua Ma</name><name sortKey="Yin, Yanni" sort="Yin, Yanni" uniqKey="Yin Y" first="Yanni" last="Yin">Yanni Yin</name><name sortKey="Yu, Fangwei" sort="Yu, Fangwei" uniqKey="Yu F" first="Fangwei" last="Yu">Fangwei Yu</name><name sortKey="Zhang, Chengqi" sort="Zhang, Chengqi" uniqKey="Zhang C" first="Chengqi" last="Zhang">Chengqi Zhang</name></country><country name="États-Unis"><region name="Texas"><name sortKey="Shim, Won Bo" sort="Shim, Won Bo" uniqKey="Shim W" first="Won-Bo" last="Shim">Won-Bo Shim</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Protein kinase FgSch9 serves as a mediator of the target of rapamycin and high osmolarity glycerol pathways and regulates multiple stress responses and secondary metabolism in Fusarium graminearum.
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